Naturally processed and concealed HLA‐A2.1‐restricted epitopes from tumor‐associated antigen tyrosinase‐related protein‐2
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چکیده
منابع مشابه
Naturally Processed Class II Epitope from the Tumor Antigen
Epithelial cell mucin Ml (I is expressed on adenocarcinomas in an underglycosylated form that serves as a tumor antigen in breast, pancre atic, ovarian, and other tumors. Two predominant MUC1-specific im mune responses arc found in patients: CDS* CTLs, which recognize tandemly repeated epitopes on the Miri protein core, and IgM antibod ies. There have been no reports to date of MUCl-specific CD...
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PURPOSE There is growing evidence that CD4(+) helper T lymphocytes (HTLs) play an essential role in the induction and long-term maintenance of antitumor CTL responses. Thus, approaches to develop effective T-cell-based immunotherapy should focus in the stimulation of both CTLs and HTLs reactive against tumor-associated antigens. The present studies were performed with the purpose of identifying...
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During immune responses, antigen-presenting cells (APCs) process antigens and present peptide epitopes complexed with human leukocyte antigen (HLA) molecules. CD4 cells recognize these naturally processed and presented epitopes (NPPEs) bound to HLA class II molecules. Epitope identification is important for developing diagnostic and therapeutic tools for immune-mediated diseases and providing i...
متن کاملNaturally processed class II epitope from the tumor antigen MUC1 primes human CD4+ T cells.
Epithelial cell mucin MUC1 is expressed on adenocarcinomas in an underglycosylated form that serves as a tumor antigen in breast, pancreatic, ovarian, and other tumors. Two predominant MUC1-specific immune responses are found in patients: CD8+ CTLs, which recognize tandemly repeated epitopes on the MUC1 protein core, and IgM antibodies. There have been no reports to date of MUC1-specific CD4+ T...
متن کاملNaturally Processed Class II Epitope from the Tumor Antigen MUC1 Primes Human CD4+ T Cells1
Epithelial cell mucin Ml (I is expressed on adenocarcinomas in an underglycosylated form that serves as a tumor antigen in breast, pancre atic, ovarian, and other tumors. Two predominant MUC1-specific im mune responses arc found in patients: CDS* CTLs, which recognize tandemly repeated epitopes on the Miri protein core, and IgM antibod ies. There have been no reports to date of MUCl-specific CD...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2000
ISSN: 0020-7136,1097-0215
DOI: 10.1002/1097-0215(20000715)87:2<241::aid-ijc15>3.3.co;2-c